The report provides state of knowledge on chemicals in plastics and based on compelling scientific evidence calls for urgent action to address chemicals in plastics as part of the global action on plastic pollution. Overview of the report The “Chemicals in Plastics: A Technical Report” aims to inform the global community about the often-overlooked chemical-related issues of plastic pollution, particularly their adverse impacts on human health and the environment as well as on resource efficiency and circularity. Based on compelling scientific evidence, it further highlights the urgent need to act and outlines possible areas for action. It also aims to support the negotiation process to develop the instrument on plastic pollution based on the United Nations Environment Assembly resolution 5/14. The report outlines a set of credible and publicly available scientific studies and initiatives focused on chemicals in plastics and the science-policy interface. The report was developed by UNEP in cooperation with the Secretariat of the Basel Convention on the Control of Transboundary Movements of Hazardous Wastes and Their Disposal, the Rotterdam Convention on the Prior Informed Consent Procedure for Certain Hazardous Chemicals and Pesticides in International Trade, and the Stockholm Convention on Persistent Organic Pollutants, with lead authors from the International Panel on Chemical Pollution, as well as contributions from key experts. Some key findings Based on the latest studies, more than 13,000 chemicals have been identified as associated with plastics and plastic production across a wide range of applications. Ten groups of chemicals (based on chemistry, uses, or sources) are identified as being of major concern due to their high toxicity and potential to migrate or be released from plastics. These include specific flame retardants, certain UV stabilizers, per- and polyfluoroalkyl substances (PFASs), phthalates, bisphenols, alkylphenols and alkylphenol ethoxylates, biocides, certain metals and metalloids, polycyclic aromatic hydrocarbons, and many other non-intentionally added substances (NIAS). Chemicals of concern have been found in plastics across a wide range of sectors and products value chains, including toys and other children's products, packaging (including food contact materials), electrical and electronic equipment, vehicles, synthetic textiles and related materials, furniture, building materials, medical devices, personal care and household products, and agriculture, aquaculture and fisheries. Chemicals of concern in plastics can impact our health and our environment: Extensive scientific data on the potential adverse impacts of about 7,000 substances associated with plastics show that more than 3,200 of them have one or more hazardous properties of concern. Women and children are particularly susceptible to these toxic chemicals. Exposures can have severe or long-lasting adverse effects on several key periods of a women’s life and may impact the next generations. Exposures during fetal development and in children can cause, for example, neurodevelopmental/neurobehavioral-related disorders. Men are not spared either, with the latest research documenting substantial detrimental effects on male fertility due to current combined exposures to hazardous chemicals, many of which are associated with plastics. Chemicals of concern can be released from plastic along its entire life cycle, during not only the extraction of raw materials, production of polymers and manufacture of plastic products, but also the use of plastic products and at the end of their life, particularly when waste is not properly managed, finding their way to the air, water and soils. Existing evidence calls for urgent action to address chemicals in plastics as part of the global action on plastic pollution, to protect human health and the environment, and transition to a toxic-free and sustainable circular economy. UNEP acknowledges the financial support from the Government of Norway, the Government of Sweden and the Government of Switzerland, for the development of the report. Read also: Chemicals are an integral part of plastics